Angiotensin II Antibody
Product Subcategory:Rabbit Polyclonal Antibody
Cat. No:251229
Unit:0.1 mg
Isotype:Rabbit Ig
Accession No:P01019
Applications:E, WB, IHC
Species Reactivity:H, M, R
Application Notes:E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Antigen:KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human angiotensinogen II.

Format:Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Alternate Names:Ang-II; Ang II; Angiotensin II; Angiotensin-2; AGT; Angiotensinogen; Serpin A8

Storage:Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Description:
Angiotensin II is an essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. In response to lowered blood pressure, the enzyme renin cleaves angiotensinogen to produce angiotensin I (angiotensin 1-10). Angiotensin I is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin II (angiotensin 1-8). Angiotensin II acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ABIlity to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone. Genetic variations in angiotensin II are a cause of susceptibility to essential hypertension (EHT). Essential hypertension is a condition in which blood pressure is consistently higher than normal with no identifiable cause.

Product Citations(产品文献):
[1] Wang C. et al. 2015-September. J Cardiovasc Pharmacol. 66(3):285-293. PMID# 25955575 [2] Wang C. et al. 2015- July. Acta Biochim Biophys Sin (Shanghai)47(7):539-547. PMID# 26071572. [3] Matsuura-Hachiya Y et al. 2013. Biochem. Biophys. res. Commun. 442(1-2):34-43. PMID# 24216112